Drug interactions
Phenobarbital + Sotalol
Severity: Minor
Phenobarbital and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces hepatic enzymes and reduces levels of many hepatically cleared beta-blockers. Sotalol is eliminated mainly unchanged by the kidneys, so a clinically significant effect is unlikely.
What this interaction means in plain words
Phenobarbital and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction has little effect because sotalol is not significantly metabolized.
What to do
No routine dose change is needed. Monitor heart rate and blood pressure if clinical response appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Phenobarbital with Sotalol?
MediHelp rates the interaction as minor. Phenobarbital and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital induces hepatic enzymes and reduces levels of many hepatically cleared beta-blockers. Sotalol is eliminated mainly unchanged by the kidneys, so a clinically significant effect is unlikely.
How serious is the interaction between Phenobarbital and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor heart rate and blood pressure if clinical response appears reduced.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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