Drug interactions
Phenobarbital + Temsirolimus
Severity: Moderate
Phenobarbital and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a CYP3A4 inducer and can lower temsirolimus and sirolimus exposure, potentially reducing antitumor efficacy. The effect builds over days to weeks and persists after discontinuation.
What this interaction means in plain words
Phenobarbital and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by phenobarbital increases temsirolimus metabolism.
What to do
Use a non-inducing anticonvulsant if possible; otherwise monitor for reduced response and consider the labeled temsirolimus dose increase for sustained use of strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Phenobarbital with Temsirolimus?
MediHelp rates the interaction as moderate. Phenobarbital and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a CYP3A4 inducer and can lower temsirolimus and sirolimus exposure, potentially reducing antitumor efficacy. The effect builds over days to weeks and persists after discontinuation.
How serious is the interaction between Phenobarbital and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant if possible; otherwise monitor for reduced response and consider the labeled temsirolimus dose increase for sustained use of strong inducers.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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