Drug interactions
Phenoxybenzamine + Sotalol
Severity: Moderate
Phenoxybenzamine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an irreversible alpha-blocker, and with sotalol hypotension, including orthostatic hypotension, can be additive. In pheochromocytoma, beta-blockers should not be given before alpha-blockade is established.
What this interaction means in plain words
Phenoxybenzamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from alpha-adrenergic and beta-adrenergic blockade.
What to do
Monitor supine and standing blood pressure and adjust doses; in pheochromocytoma, start the beta-blocker only after adequate alpha-blockade.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Phenoxybenzamine with Sotalol?
MediHelp rates the interaction as moderate. Phenoxybenzamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is an irreversible alpha-blocker, and with sotalol hypotension, including orthostatic hypotension, can be additive. In pheochromocytoma, beta-blockers should not be given before alpha-blockade is established.
How serious is the interaction between Phenoxybenzamine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and adjust doses; in pheochromocytoma, start the beta-blocker only after adequate alpha-blockade.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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