Drug interactions
Phentermine + Salmeterol
Severity: Moderate
Phentermine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic amine and combined with salmeterol may add to increases in heart rate and blood pressure, palpitations and tremor. Patients with cardiovascular disease are most at risk.
What this interaction means in plain words
Phentermine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phentermine belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive sympathomimetic (adrenergic) stimulation.
What to do
Monitor heart rate and blood pressure and ask about palpitations; avoid in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Phentermine with Salmeterol?
MediHelp rates the interaction as moderate. Phentermine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine is a sympathomimetic amine and combined with salmeterol may add to increases in heart rate and blood pressure, palpitations and tremor. Patients with cardiovascular disease are most at risk.
How serious is the interaction between Phentermine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and ask about palpitations; avoid in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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