Drug interactions
Phentolamine + Sulindac
Severity: Minor
Phentolamine and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly diminish the blood pressure lowering effect of vasodilating antihypertensives. Clinical data for phentolamine specifically are scarce, and the effect is likely small.
What this interaction means in plain words
Phentolamine and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phentolamine belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium retention may oppose alpha-blockade, though this is largely theoretical for phentolamine.
What to do
Be aware that blood pressure response may be reduced and check blood pressure if sulindac is added or withdrawn.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Phentolamine with Sulindac?
MediHelp rates the interaction as minor. Phentolamine and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may modestly diminish the blood pressure lowering effect of vasodilating antihypertensives. Clinical data for phentolamine specifically are scarce, and the effect is likely small.
How serious is the interaction between Phentolamine and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware that blood pressure response may be reduced and check blood pressure if sulindac is added or withdrawn.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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