Drug interactions
Phentolamine + Tolfenamic acid
Severity: Minor
Phentolamine and Tolfenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt blood pressure lowering effects of antihypertensive drugs through sodium and water retention and reduced vasodilatory prostaglandins. The effect on phentolamine is theoretical and probably small.
What this interaction means in plain words
Phentolamine and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phentolamine belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis may counter vasodilation and cause fluid retention.
What to do
Monitor blood pressure if tolfenamic acid is used regularly with phentolamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phentolamine
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Phentolamine with Tolfenamic acid?
MediHelp rates the interaction as minor. Phentolamine and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can blunt blood pressure lowering effects of antihypertensive drugs through sodium and water retention and reduced vasodilatory prostaglandins. The effect on phentolamine is theoretical and probably small.
How serious is the interaction between Phentolamine and Tolfenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if tolfenamic acid is used regularly with phentolamine.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
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