Drug interactions
Phentolamine + Treprostinil
Severity: Moderate
Phentolamine and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator that lowers blood pressure and may add to the hypotensive effect of phentolamine.
What this interaction means in plain words
Phentolamine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phentolamine belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure when combining and reduce the dose of one agent if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phentolamine
Other interactions of Treprostinil
Frequently asked questions
Can I take Phentolamine with Treprostinil?
MediHelp rates the interaction as moderate. Phentolamine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a vasodilator that lowers blood pressure and may add to the hypotensive effect of phentolamine.
How serious is the interaction between Phentolamine and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when combining and reduce the dose of one agent if hypotension develops.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
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