Drug interactions
Phentolamine + Vardenafil
Severity: Major
Phentolamine and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and together they can cause symptomatic hypotension, dizziness or syncope. Alpha-blockers combined with PDE5 inhibitors require caution.
What this interaction means in plain words
Phentolamine and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phentolamine belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and alpha-adrenergic blockade.
What to do
Avoid using together unless the patient is hemodynamically stable, and use the lowest vardenafil dose. Monitor blood pressure and counsel on orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Phentolamine
Frequently asked questions
Can I take Phentolamine with Vardenafil?
MediHelp rates the interaction as major. Phentolamine and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs lower blood pressure, and together they can cause symptomatic hypotension, dizziness or syncope. Alpha-blockers combined with PDE5 inhibitors require caution.
How serious is the interaction between Phentolamine and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together unless the patient is hemodynamically stable, and use the lowest vardenafil dose. Monitor blood pressure and counsel on orthostatic symptoms.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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