Drug interactions
Phenylephrine + Tiotropium-olodaterol
Severity: Moderate
Phenylephrine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenylephrine is an alpha-adrenergic agonist that raises blood pressure, and olodaterol adds beta-mediated tachycardia. Combined use may increase blood pressure, heart rate and palpitations, particularly with systemic phenylephrine.
What this interaction means in plain words
Phenylephrine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenylephrine belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive sympathomimetic cardiovascular stimulation.
What to do
Monitor blood pressure and heart rate, especially in patients with hypertension or coronary disease. Avoid systemic decongestants where possible in these patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Frequently asked questions
Can I take Phenylephrine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Phenylephrine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenylephrine is an alpha-adrenergic agonist that raises blood pressure, and olodaterol adds beta-mediated tachycardia. Combined use may increase blood pressure, heart rate and palpitations, particularly with systemic phenylephrine.
How serious is the interaction between Phenylephrine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially in patients with hypertension or coronary disease. Avoid systemic decongestants where possible in these patients.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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