Drug interactions
Phenytoin + Polatuzumab vedotin
Severity: Moderate
Phenytoin and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may lower exposure to MMAE, the cytotoxic component of polatuzumab vedotin. This could reduce antitumor efficacy.
What this interaction means in plain words
Phenytoin and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenytoin belongs to Central Nervous System; Polatuzumab vedotin belongs to Oncology.
Why it happens
Phenytoin induces CYP3A4, increasing MMAE metabolism.
What to do
Consider a non-inducing anticonvulsant, such as levetiracetam, during polatuzumab therapy, and monitor for reduced tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Phenytoin with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Phenytoin and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP3A4 and may lower exposure to MMAE, the cytotoxic component of polatuzumab vedotin. This could reduce antitumor efficacy.
How serious is the interaction between Phenytoin and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-inducing anticonvulsant, such as levetiracetam, during polatuzumab therapy, and monitor for reduced tumor response.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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