Drug interactions
Phenytoin + Repotrectinib
Severity: Major
Phenytoin and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin can lower repotrectinib concentrations through CYP3A4 induction, risking loss of antitumor effect. Repotrectinib is itself a CYP3A4 inducer and may in turn reduce phenytoin levels, risking breakthrough seizures.
What this interaction means in plain words
Phenytoin and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Phenytoin belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Mutual CYP3A4 induction accelerates the metabolism of both drugs.
What to do
Avoid the combination and use a non-inducing antiseizure agent. If unavoidable, monitor phenytoin concentrations and seizure control, and tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Phenytoin with Repotrectinib?
MediHelp rates the interaction as major. Phenytoin and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin can lower repotrectinib concentrations through CYP3A4 induction, risking loss of antitumor effect. Repotrectinib is itself a CYP3A4 inducer and may in turn reduce phenytoin levels, risking breakthrough seizures.
How serious is the interaction between Phenytoin and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing antiseizure agent. If unavoidable, monitor phenytoin concentrations and seizure control, and tumor response.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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