Drug interactions
Phenytoin + Vorasidenib
Severity: Moderate
Phenytoin and Vorasidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may induce CYP1A2 and lower vorasidenib plasma levels. Reduced exposure could weaken antitumor efficacy.
What this interaction means in plain words
Phenytoin and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenytoin belongs to Central Nervous System; Vorasidenib belongs to Oncology.
Why it happens
Induction of CYP1A2 (and possibly other enzymes) increasing vorasidenib metabolism.
What to do
Avoid the combination where possible and consider a non-inducing antiseizure drug. If unavoidable, monitor disease response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vorasidenib
- Ciprofloxacin + Vorasidenib Major
- Fluvoxamine + Vorasidenib Major
- Tacrolimus + Vorasidenib Major
- Vorasidenib + Warfarin Major
- Midazolam + Vorasidenib Moderate
- Rifampicin + Vorasidenib Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Phenytoin with Vorasidenib?
MediHelp rates the interaction as moderate. Phenytoin and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin may induce CYP1A2 and lower vorasidenib plasma levels. Reduced exposure could weaken antitumor efficacy.
How serious is the interaction between Phenytoin and Vorasidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider a non-inducing antiseizure drug. If unavoidable, monitor disease response closely.
What other medicines interact with Vorasidenib?
MediHelp also lists interactions of Vorasidenib with, for example, Ciprofloxacin, Fluvoxamine, Tacrolimus. The full list is on the Vorasidenib page.
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