Drug interactions
Vorasidenib + Warfarin
Severity: Major
Vorasidenib and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorasidenib can induce several CYP enzymes, including those that metabolize warfarin. Warfarin levels may fall, reducing anticoagulation and raising the risk of thrombosis.
What this interaction means in plain words
Vorasidenib and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vorasidenib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Induction of CYP2C9 and other CYP enzymes by vorasidenib increases warfarin clearance.
What to do
Avoid the combination where possible. If used together, check INR frequently and adjust the warfarin dose, including after vorasidenib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vorasidenib
- Ciprofloxacin + Vorasidenib Major
- Fluvoxamine + Vorasidenib Major
- Tacrolimus + Vorasidenib Major
- Midazolam + Vorasidenib Moderate
- Phenytoin + Vorasidenib Moderate
- Rifampicin + Vorasidenib Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Vorasidenib with Warfarin?
MediHelp rates the interaction as major. Vorasidenib and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorasidenib can induce several CYP enzymes, including those that metabolize warfarin. Warfarin levels may fall, reducing anticoagulation and raising the risk of thrombosis.
How serious is the interaction between Vorasidenib and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, check INR frequently and adjust the warfarin dose, including after vorasidenib is stopped.
What other medicines interact with Vorasidenib?
MediHelp also lists interactions of Vorasidenib with, for example, Ciprofloxacin, Fluvoxamine, Tacrolimus. The full list is on the Vorasidenib page.
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