Drug interactions
Ciprofloxacin + Vorasidenib
Severity: Major
Ciprofloxacin and Vorasidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a strong CYP1A2 inhibitor and can increase systemic exposure to vorasidenib, which is cleared mainly by CYP1A2. Higher exposure may increase hepatotoxicity and other adverse effects.
What this interaction means in plain words
Ciprofloxacin and Vorasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Vorasidenib belongs to Oncology.
Why it happens
Inhibition of CYP1A2 by ciprofloxacin decreases vorasidenib metabolism.
What to do
Use an antibiotic from a different class that does not inhibit CYP1A2. If unavoidable, monitor liver enzymes and for adverse reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vorasidenib
- Fluvoxamine + Vorasidenib Major
- Tacrolimus + Vorasidenib Major
- Vorasidenib + Warfarin Major
- Midazolam + Vorasidenib Moderate
- Phenytoin + Vorasidenib Moderate
- Rifampicin + Vorasidenib Moderate
Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Vorasidenib?
MediHelp rates the interaction as major. Ciprofloxacin and Vorasidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciprofloxacin is a strong CYP1A2 inhibitor and can increase systemic exposure to vorasidenib, which is cleared mainly by CYP1A2. Higher exposure may increase hepatotoxicity and other adverse effects.
How serious is the interaction between Ciprofloxacin and Vorasidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antibiotic from a different class that does not inhibit CYP1A2. If unavoidable, monitor liver enzymes and for adverse reactions.
What other medicines interact with Vorasidenib?
MediHelp also lists interactions of Vorasidenib with, for example, Fluvoxamine, Tacrolimus, Warfarin. The full list is on the Vorasidenib page.
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