Drug interactions
Midazolam + Vorasidenib
Severity: Moderate
Midazolam and Vorasidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorasidenib may induce CYP3A4 and reduce midazolam exposure. Sedation or anxiolysis may be less effective than expected.
What this interaction means in plain words
Midazolam and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Vorasidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 increasing midazolam metabolism.
What to do
Monitor sedation response and titrate midazolam to effect. Consider an alternative not dependent on CYP3A4 if efficacy is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vorasidenib
- Ciprofloxacin + Vorasidenib Major
- Fluvoxamine + Vorasidenib Major
- Tacrolimus + Vorasidenib Major
- Vorasidenib + Warfarin Major
- Phenytoin + Vorasidenib Moderate
- Rifampicin + Vorasidenib Moderate
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Vorasidenib?
MediHelp rates the interaction as moderate. Midazolam and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorasidenib may induce CYP3A4 and reduce midazolam exposure. Sedation or anxiolysis may be less effective than expected.
How serious is the interaction between Midazolam and Vorasidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation response and titrate midazolam to effect. Consider an alternative not dependent on CYP3A4 if efficacy is inadequate.
What other medicines interact with Vorasidenib?
MediHelp also lists interactions of Vorasidenib with, for example, Ciprofloxacin, Fluvoxamine, Tacrolimus. The full list is on the Vorasidenib page.
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