Drug interactions
Rifampicin + Vorasidenib
Severity: Moderate
Rifampicin and Vorasidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin may lower vorasidenib concentrations through enzyme induction. This could reduce efficacy in glioma treatment.
What this interaction means in plain words
Rifampicin and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifampicin belongs to Anti Bacterial; Vorasidenib belongs to Oncology.
Why it happens
Induction of CYP1A2 and other metabolic enzymes accelerating vorasidenib clearance.
What to do
Consider alternatives to rifampicin when possible. If it is required, monitor tumor response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vorasidenib
- Ciprofloxacin + Vorasidenib Major
- Fluvoxamine + Vorasidenib Major
- Tacrolimus + Vorasidenib Major
- Vorasidenib + Warfarin Major
- Midazolam + Vorasidenib Moderate
- Phenytoin + Vorasidenib Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Vorasidenib?
MediHelp rates the interaction as moderate. Rifampicin and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin may lower vorasidenib concentrations through enzyme induction. This could reduce efficacy in glioma treatment.
How serious is the interaction between Rifampicin and Vorasidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternatives to rifampicin when possible. If it is required, monitor tumor response closely.
What other medicines interact with Vorasidenib?
MediHelp also lists interactions of Vorasidenib with, for example, Ciprofloxacin, Fluvoxamine, Tacrolimus. The full list is on the Vorasidenib page.
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