Drug interactions
Pholcodine + Trimipramine
Severity: Minor
Pholcodine and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid antitussive with mild sedative properties, and combining it with trimipramine may increase drowsiness. The sedative interaction is generally modest at antitussive doses.
What this interaction means in plain words
Pholcodine and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects.
What to do
Advise patients about possible drowsiness and avoidance of alcohol and driving until the response is known. Keep to the recommended antitussive dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Pholcodine with Trimipramine?
MediHelp rates the interaction as minor. Pholcodine and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pholcodine is an opioid antitussive with mild sedative properties, and combining it with trimipramine may increase drowsiness. The sedative interaction is generally modest at antitussive doses.
How serious is the interaction between Pholcodine and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about possible drowsiness and avoidance of alcohol and driving until the response is known. Keep to the recommended antitussive dose.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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