Drug interactions
Physostigmine + Tiotropium-olodaterol
Severity: Minor
Physostigmine and Tiotropium-olodaterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Physostigmine inhibits acetylcholinesterase and raises acetylcholine, while tiotropium blocks muscarinic receptors, so the two have opposing actions. The antimuscarinic effect of tiotropium may be partially reduced, and the clinical significance is usually small.
What this interaction means in plain words
Physostigmine and Tiotropium-olodaterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
No dose change is generally needed. Watch for reduced bronchodilator response or cholinergic effects such as bronchial secretions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Physostigmine with Tiotropium-olodaterol?
MediHelp rates the interaction as minor. Physostigmine and Tiotropium-olodaterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Physostigmine inhibits acetylcholinesterase and raises acetylcholine, while tiotropium blocks muscarinic receptors, so the two have opposing actions. The antimuscarinic effect of tiotropium may be partially reduced, and the clinical significance is usually small.
How serious is the interaction between Physostigmine and Tiotropium-olodaterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Watch for reduced bronchodilator response or cholinergic effects such as bronchial secretions.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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