Drug interactions
Pimavanserin + Solifenacin
Severity: Moderate
Pimavanserin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin prolongs the QT interval and solifenacin has a minor additive effect. Together they may increase the risk of ventricular arrhythmia, particularly in older patients with other risk factors.
What this interaction means in plain words
Pimavanserin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the baseline ECG and electrolytes, and avoid the pair in patients with known long QT. Monitor the QTc if both are required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Pimavanserin with Solifenacin?
MediHelp rates the interaction as moderate. Pimavanserin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin prolongs the QT interval and solifenacin has a minor additive effect. Together they may increase the risk of ventricular arrhythmia, particularly in older patients with other risk factors.
How serious is the interaction between Pimavanserin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline ECG and electrolytes, and avoid the pair in patients with known long QT. Monitor the QTc if both are required.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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