Drug interactions
Pimavanserin + Tazemetostat
Severity: Moderate
Pimavanserin and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may modestly reduce pimavanserin levels. The effect on clinical response is likely limited.
What this interaction means in plain words
Pimavanserin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing pimavanserin metabolism.
What to do
Monitor for reduced antipsychotic effect and adjust the pimavanserin dose if symptoms re-emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Pimavanserin with Tazemetostat?
MediHelp rates the interaction as moderate. Pimavanserin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak to moderate CYP3A4 inducer and may modestly reduce pimavanserin levels. The effect on clinical response is likely limited.
How serious is the interaction between Pimavanserin and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antipsychotic effect and adjust the pimavanserin dose if symptoms re-emerge.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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