Drug interactions
Pimavanserin + Tecovirimat
Severity: Minor
Pimavanserin and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and could slightly lower pimavanserin exposure. Given the short course of tecovirimat, a meaningful loss of effect is unlikely.
What this interaction means in plain words
Pimavanserin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pimavanserin belongs to Central Nervous System; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 increases pimavanserin clearance.
What to do
No empiric dose change is needed; monitor psychotic symptoms during and shortly after the tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Pimavanserin with Tecovirimat?
MediHelp rates the interaction as minor. Pimavanserin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and could slightly lower pimavanserin exposure. Given the short course of tecovirimat, a meaningful loss of effect is unlikely.
How serious is the interaction between Pimavanserin and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor psychotic symptoms during and shortly after the tecovirimat course.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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