Drug interactions
Pimavanserin + Vemurafenib
Severity: Major
Pimavanserin and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval, and pimavanserin has a similar effect, so the combination can raise the risk of ventricular arrhythmias. Vemurafenib also induces CYP3A4 weakly to moderately, which may lower pimavanserin levels.
What this interaction means in plain words
Pimavanserin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimavanserin belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive QTc prolongation, with possible CYP3A4 induction by vemurafenib.
What to do
Obtain baseline and periodic ECGs and correct electrolytes. Avoid if QTc is elevated, and consider alternatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Pimavanserin with Vemurafenib?
MediHelp rates the interaction as major. Pimavanserin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval, and pimavanserin has a similar effect, so the combination can raise the risk of ventricular arrhythmias. Vemurafenib also induces CYP3A4 weakly to moderately, which may lower pimavanserin levels.
How serious is the interaction between Pimavanserin and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct electrolytes. Avoid if QTc is elevated, and consider alternatives.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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