Drug interactions
Pimavanserin + Vorinostat
Severity: Moderate
Pimavanserin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QTc prolongation, and pimavanserin also prolongs the QT interval, so the combination may increase arrhythmia risk.
What this interaction means in plain words
Pimavanserin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG and monitor QTc and potassium and magnesium during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Pimavanserin with Vorinostat?
MediHelp rates the interaction as moderate. Pimavanserin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QTc prolongation, and pimavanserin also prolongs the QT interval, so the combination may increase arrhythmia risk.
How serious is the interaction between Pimavanserin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and potassium and magnesium during combined use.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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