Drug interactions
Pimozide + Prochlorperazine
Severity: Contraindicated
Pimozide and Prochlorperazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling advises against combination with other antipsychotics.
What this interaction means in plain words
Pimozide and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade, plus additive dopamine antagonism.
What to do
Do not combine; choose a non-QT-prolonging antiemetic if prochlorperazine is for nausea. Correct electrolytes and review other QT-prolonging drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
- Amisulpride + Prochlorperazine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Prochlorperazine?
MediHelp rates the interaction as contraindicated. Pimozide and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents can prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling advises against combination with other antipsychotics.
How serious is the interaction between Pimozide and Prochlorperazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-QT-prolonging antiemetic if prochlorperazine is for nausea. Correct electrolytes and review other QT-prolonging drugs.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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