Drug interactions
Nilotinib + Prochlorperazine
Severity: Contraindicated
Nilotinib and Prochlorperazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and sudden death, and prochlorperazine adds further risk. The combination should be avoided.
What this interaction means in plain words
Nilotinib and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nilotinib belongs to Oncology; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation via cardiac repolarization inhibition.
What to do
Avoid the combination and select a non-QT-prolonging antiemetic. If unavoidable, monitor the ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
- Amisulpride + Prochlorperazine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Prochlorperazine?
MediHelp rates the interaction as contraindicated. Nilotinib and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and prochlorperazine adds further risk. The combination should be avoided.
How serious is the interaction between Nilotinib and Prochlorperazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-QT-prolonging antiemetic. If unavoidable, monitor the ECG and electrolytes closely.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Pimozide. The full list is on the Prochlorperazine page.
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