Drug interactions
Dronedarone + Prochlorperazine
Severity: Contraindicated
Dronedarone and Prochlorperazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and phenothiazines add to this effect. The combination is a recognised risk for torsades de pointes, and dronedarone labeling advises against QT-prolonging phenothiazines.
What this interaction means in plain words
Dronedarone and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Do not co-administer; use a non-QT-prolonging antiemetic for the duration of dronedarone treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Prochlorperazine
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
- Amisulpride + Prochlorperazine Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Prochlorperazine?
MediHelp rates the interaction as contraindicated. Dronedarone and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronedarone prolongs the QT interval and phenothiazines add to this effect. The combination is a recognised risk for torsades de pointes, and dronedarone labeling advises against QT-prolonging phenothiazines.
How serious is the interaction between Dronedarone and Prochlorperazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-QT-prolonging antiemetic for the duration of dronedarone treatment.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Ibutilide, Nilotinib, Pimozide. The full list is on the Prochlorperazine page.
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