Drug interactions
Ibutilide + Prochlorperazine
Severity: Contraindicated
Ibutilide and Prochlorperazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide has a high intrinsic risk of torsades de pointes, and phenothiazines like prochlorperazine can add further QT prolongation. The combination can precipitate serious ventricular arrhythmias.
What this interaction means in plain words
Ibutilide and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac potassium channels prolonging the QT interval.
What to do
Avoid giving prochlorperazine around ibutilide infusion; use a non-QT-prolonging antiemetic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
- Amisulpride + Prochlorperazine Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Prochlorperazine?
MediHelp rates the interaction as contraindicated. Ibutilide and Prochlorperazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide has a high intrinsic risk of torsades de pointes, and phenothiazines like prochlorperazine can add further QT prolongation. The combination can precipitate serious ventricular arrhythmias.
How serious is the interaction between Ibutilide and Prochlorperazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving prochlorperazine around ibutilide infusion; use a non-QT-prolonging antiemetic.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Nilotinib, Pimozide. The full list is on the Prochlorperazine page.
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