Drug interactions
Pimozide + Repotrectinib
Severity: Moderate
Pimozide and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 inducer and may reduce pimozide concentrations. This can lead to reduced control of the condition being treated.
What this interaction means in plain words
Pimozide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction by repotrectinib increases pimozide clearance.
What to do
Avoid if possible; if combined, monitor for loss of pimozide effect and adjust the dose with ECG monitoring. Reassess when repotrectinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Pimozide with Repotrectinib?
MediHelp rates the interaction as moderate. Pimozide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is a CYP3A4 inducer and may reduce pimozide concentrations. This can lead to reduced control of the condition being treated.
How serious is the interaction between Pimozide and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, monitor for loss of pimozide effect and adjust the dose with ECG monitoring. Reassess when repotrectinib is stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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