Drug interactions
Pimozide + Rizatriptan
Severity: Minor
Pimozide and Rizatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been theorised with triptans and antipsychotics, but the clinical risk is low. Rizatriptan is metabolised by MAO-A rather than CYP enzymes, so there is no relevant pharmacokinetic interaction.
What this interaction means in plain words
Pimozide and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pimozide belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; mostly theoretical.
What to do
No routine change is needed; advise the patient to report agitation, tremor, fever or diarrhea. Evaluate promptly if symptoms of serotonin toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Pimozide with Rizatriptan?
MediHelp rates the interaction as minor. Pimozide and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonin syndrome has been theorised with triptans and antipsychotics, but the clinical risk is low. Rizatriptan is metabolised by MAO-A rather than CYP enzymes, so there is no relevant pharmacokinetic interaction.
How serious is the interaction between Pimozide and Rizatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise the patient to report agitation, tremor, fever or diarrhea. Evaluate promptly if symptoms of serotonin toxicity appear.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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