Drug interactions
Pimozide + Sevoflurane
Severity: Major
Pimozide and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and pimozide is a strong QT-prolonging drug. During anesthesia this increases the risk of torsades de pointes.
What this interaction means in plain words
Pimozide and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Alert the anesthesia team to pimozide use and obtain a pre-operative ECG. Correct electrolytes and monitor the ECG continuously during and after the procedure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Pimozide with Sevoflurane?
MediHelp rates the interaction as major. Pimozide and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sevoflurane can prolong the QT interval, and pimozide is a strong QT-prolonging drug. During anesthesia this increases the risk of torsades de pointes.
How serious is the interaction between Pimozide and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Alert the anesthesia team to pimozide use and obtain a pre-operative ECG. Correct electrolytes and monitor the ECG continuously during and after the procedure.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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