Drug interactions
Pimozide + Tiotropium-olodaterol
Severity: Major
Pimozide and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide markedly prolongs the QT interval and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation, raising the risk of torsades de pointes. Pimozide also has some anticholinergic activity that may add to tiotropium effects.
What this interaction means in plain words
Pimozide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-mediated hypokalemia, with additive antimuscarinic effects.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy. Consider an alternative bronchodilator if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Pimozide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide markedly prolongs the QT interval and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation, raising the risk of torsades de pointes. Pimozide also has some anticholinergic activity that may add to tiotropium effects.
How serious is the interaction between Pimozide and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy. Consider an alternative bronchodilator if the QTc becomes significantly prolonged.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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