Drug interactions
Pimozide + Toremifene
Severity: Contraindicated
Pimozide and Toremifene: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling advises against co-administration with other QT-prolonging agents.
What this interaction means in plain words
Pimozide and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Toremifene belongs to Endocrine.
Why it happens
Additive blockade of cardiac repolarizing potassium currents (hERG) causing QT prolongation.
What to do
Avoid the combination and choose an antiestrogen or antipsychotic alternative without QT liability. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
- Thioridazine + Toremifene Contraindicated
Frequently asked questions
Can I take Pimozide with Toremifene?
MediHelp rates the interaction as contraindicated. Pimozide and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combining them raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling advises against co-administration with other QT-prolonging agents.
How serious is the interaction between Pimozide and Toremifene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiestrogen or antipsychotic alternative without QT liability. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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