Drug interactions
Amiodarone + Toremifene
Severity: Contraindicated
Amiodarone and Toremifene: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene prolongs the QT interval in a dose-related manner, and combining it with amiodarone raises the risk of torsades de pointes and sudden death. Toremifene labeling advises against use with QT-prolonging drugs.
What this interaction means in plain words
Amiodarone and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Additive prolongation of the QT interval through blockade of cardiac repolarizing potassium currents.
What to do
Avoid the combination and choose an alternative antiestrogen or antiarrhythmic. If amiodarone is essential, interrupt toremifene and monitor ECG closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Toremifene
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
- Thioridazine + Toremifene Contraindicated
Frequently asked questions
Can I take Amiodarone with Toremifene?
MediHelp rates the interaction as contraindicated. Amiodarone and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Toremifene prolongs the QT interval in a dose-related manner, and combining it with amiodarone raises the risk of torsades de pointes and sudden death. Toremifene labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Amiodarone and Toremifene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiestrogen or antiarrhythmic. If amiodarone is essential, interrupt toremifene and monitor ECG closely.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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