Drug interactions
Dronedarone + Toremifene
Severity: Contraindicated
Dronedarone and Toremifene: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene prolongs the QT interval in a dose-related way, and dronedarone has similar effects. Together they raise the risk of torsades de pointes.
What this interaction means in plain words
Dronedarone and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Do not combine; select an alternative endocrine therapy or rhythm control agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
- Thioridazine + Toremifene Contraindicated
Frequently asked questions
Can I take Dronedarone with Toremifene?
MediHelp rates the interaction as contraindicated. Dronedarone and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Toremifene prolongs the QT interval in a dose-related way, and dronedarone has similar effects. Together they raise the risk of torsades de pointes.
How serious is the interaction between Dronedarone and Toremifene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative endocrine therapy or rhythm control agent.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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