Drug interactions
Nilotinib + Toremifene
Severity: Contraindicated
Nilotinib and Toremifene: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and toremifene labeling warns against combination with other QT-prolonging agents. Concurrent use raises the risk of torsades de pointes.
What this interaction means in plain words
Nilotinib and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nilotinib belongs to Oncology; Toremifene belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination and use an alternative endocrine agent. If unavoidable, correct electrolytes and monitor ECG.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
- Thioridazine + Toremifene Contraindicated
Frequently asked questions
Can I take Nilotinib with Toremifene?
MediHelp rates the interaction as contraindicated. Nilotinib and Toremifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and toremifene labeling warns against combination with other QT-prolonging agents. Concurrent use raises the risk of torsades de pointes.
How serious is the interaction between Nilotinib and Toremifene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative endocrine agent. If unavoidable, correct electrolytes and monitor ECG.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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