Drug interactions
Pimozide + Triclabendazole
Severity: Major
Pimozide and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval and pimozide is a strongly QT-prolonging drug, so combining them increases the risk of torsades de pointes. Triclabendazole metabolism involves CYP enzymes, but the main concern is additive repolarization effects.
What this interaction means in plain words
Pimozide and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Avoid the combination if an alternative exists. If used, obtain a baseline ECG, correct potassium and magnesium, and repeat the ECG during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Pimozide with Triclabendazole?
MediHelp rates the interaction as major. Pimozide and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triclabendazole can prolong the QT interval and pimozide is a strongly QT-prolonging drug, so combining them increases the risk of torsades de pointes. Triclabendazole metabolism involves CYP enzymes, but the main concern is additive repolarization effects.
How serious is the interaction between Pimozide and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If used, obtain a baseline ECG, correct potassium and magnesium, and repeat the ECG during treatment.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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