Drug interactions
Pindolol + Sevoflurane
Severity: Moderate
Pindolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol combined with sevoflurane can cause additive hypotension and bradycardia through reduced cardiac output. Pindolol's partial agonist activity may moderate the effect on heart rate somewhat.
What this interaction means in plain words
Pindolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative inotropic and chronotropic effects with anesthetic vasodilation.
What to do
Generally continue the beta-blocker through surgery and monitor blood pressure, heart rate and ECG. Treat hypotension or bradycardia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pindolol and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sevoflurane
Frequently asked questions
Can I take Pindolol with Sevoflurane?
MediHelp rates the interaction as moderate. Pindolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pindolol combined with sevoflurane can cause additive hypotension and bradycardia through reduced cardiac output. Pindolol's partial agonist activity may moderate the effect on heart rate somewhat.
How serious is the interaction between Pindolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue the beta-blocker through surgery and monitor blood pressure, heart rate and ECG. Treat hypotension or bradycardia promptly.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
