Drug interactions
Pioglitazone + Rosuvastatin
Severity: Minor
Pioglitazone and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone has weak OATP1B1 inhibitory activity in vitro, but no meaningful effect on rosuvastatin exposure has been demonstrated. The two drugs are often used together without problems.
What this interaction means in plain words
Pioglitazone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pioglitazone belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Theoretical weak OATP1B1 inhibition by pioglitazone; clinical relevance is not established.
What to do
No dose adjustment is needed. Review any muscle symptoms as for any statin user.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Pioglitazone
Frequently asked questions
Can I take Pioglitazone with Rosuvastatin?
MediHelp rates the interaction as minor. Pioglitazone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone has weak OATP1B1 inhibitory activity in vitro, but no meaningful effect on rosuvastatin exposure has been demonstrated. The two drugs are often used together without problems.
How serious is the interaction between Pioglitazone and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Review any muscle symptoms as for any statin user.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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