Drug interactions
Pioglitazone + Tecovirimat
Severity: Moderate
Pioglitazone and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C8 and may modestly raise pioglitazone levels, increasing the chance of hypoglycemia.
What this interaction means in plain words
Pioglitazone and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pioglitazone belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP2C8 inhibition reduces pioglitazone metabolism.
What to do
Monitor blood glucose and for hypoglycemia symptoms during the tecovirimat course, adjusting pioglitazone if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Pioglitazone with Tecovirimat?
MediHelp rates the interaction as moderate. Pioglitazone and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat weakly inhibits CYP2C8 and may modestly raise pioglitazone levels, increasing the chance of hypoglycemia.
How serious is the interaction between Pioglitazone and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for hypoglycemia symptoms during the tecovirimat course, adjusting pioglitazone if needed.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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