Drug interactions
Pioglitazone + Tipranavir
Severity: Moderate
Pioglitazone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir boosted with ritonavir has complex enzyme effects and protease inhibitors may cause insulin resistance and hyperglycemia. Pioglitazone's glucose control may therefore change unpredictably.
What this interaction means in plain words
Pioglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pioglitazone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Mixed enzyme effects on pioglitazone metabolism plus protease inhibitor-related insulin resistance.
What to do
Monitor blood glucose closely and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Pioglitazone with Tipranavir?
MediHelp rates the interaction as moderate. Pioglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir boosted with ritonavir has complex enzyme effects and protease inhibitors may cause insulin resistance and hyperglycemia. Pioglitazone's glucose control may therefore change unpredictably.
How serious is the interaction between Pioglitazone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and adjust the antidiabetic regimen as needed.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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