Drug interactions
Pioglitazone + Voriconazole
Severity: Minor
Pioglitazone and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may modestly increase pioglitazone exposure, though pioglitazone is cleared mainly by CYP2C8 with a smaller CYP3A4 contribution. Effects on glucose control or fluid retention are typically small.
What this interaction means in plain words
Pioglitazone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pioglitazone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Partial inhibition of CYP3A4-mediated pioglitazone metabolism by voriconazole.
What to do
Monitor blood glucose and signs of edema when starting or stopping voriconazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pioglitazone and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Pioglitazone with Voriconazole?
MediHelp rates the interaction as minor. Pioglitazone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may modestly increase pioglitazone exposure, though pioglitazone is cleared mainly by CYP2C8 with a smaller CYP3A4 contribution. Effects on glucose control or fluid retention are typically small.
How serious is the interaction between Pioglitazone and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of edema when starting or stopping voriconazole.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
