Drug interactions
Piperacillin + Probenecid
Severity: Moderate
Piperacillin and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid prolongs piperacillin's half-life and raises its plasma levels by lowering renal clearance. This is usually not harmful but can increase beta-lactam exposure, especially in renal impairment.
What this interaction means in plain words
Piperacillin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piperacillin belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular secretion of piperacillin via organic anion transporters.
What to do
Avoid routine combination unless prolonged exposure is intended. Monitor for neurotoxicity and cytopenias in patients with renal dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Piperacillin with Probenecid?
MediHelp rates the interaction as moderate. Piperacillin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid prolongs piperacillin's half-life and raises its plasma levels by lowering renal clearance. This is usually not harmful but can increase beta-lactam exposure, especially in renal impairment.
How serious is the interaction between Piperacillin and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination unless prolonged exposure is intended. Monitor for neurotoxicity and cytopenias in patients with renal dysfunction.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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