Drug interactions
Pirbuterol + Tiotropium-olodaterol
Severity: Moderate
Pirbuterol and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirbuterol is another beta2 agonist, so using it with olodaterol duplicates beta stimulation. This may cause tachycardia, tremor, hypokalemia and arrhythmias.
What this interaction means in plain words
Pirbuterol and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic receptor agonism.
What to do
Avoid routine concurrent use of two beta agonists. Monitor heart rate and potassium if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Pirbuterol with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Pirbuterol and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirbuterol is another beta2 agonist, so using it with olodaterol duplicates beta stimulation. This may cause tachycardia, tremor, hypokalemia and arrhythmias.
How serious is the interaction between Pirbuterol and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two beta agonists. Monitor heart rate and potassium if both are used.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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