Drug interactions
Pirbuterol + Trimipramine
Severity: Moderate
Pirbuterol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine may increase the cardiovascular effects of pirbuterol, with possible tachycardia and arrhythmia, though its noradrenergic reuptake inhibition is weaker than other tricyclics.
What this interaction means in plain words
Pirbuterol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic activity may potentiate beta-agonist cardiovascular effects through altered adrenergic handling and additive cardiac effects.
What to do
Monitor heart rate, rhythm and blood pressure, and use the lowest effective pirbuterol dose. Consider alternatives if cardiac symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Pirbuterol with Trimipramine?
MediHelp rates the interaction as moderate. Pirbuterol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine may increase the cardiovascular effects of pirbuterol, with possible tachycardia and arrhythmia, though its noradrenergic reuptake inhibition is weaker than other tricyclics.
How serious is the interaction between Pirbuterol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, and use the lowest effective pirbuterol dose. Consider alternatives if cardiac symptoms develop.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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