Drug interactions
Pirfenidone + Ritlecitinib
Severity: Moderate
Pirfenidone and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2 and may raise exposure to pirfenidone, which is predominantly CYP1A2-metabolized. Higher levels may increase gastrointestinal effects, photosensitivity and hepatotoxicity.
What this interaction means in plain words
Pirfenidone and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirfenidone belongs to Miscellaneous; Ritlecitinib belongs to Oncology.
Why it happens
Ritlecitinib inhibits CYP1A2, reducing pirfenidone clearance.
What to do
Monitor for pirfenidone adverse effects and liver enzymes, and reduce the pirfenidone dose if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Pirfenidone with Ritlecitinib?
MediHelp rates the interaction as moderate. Pirfenidone and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2 and may raise exposure to pirfenidone, which is predominantly CYP1A2-metabolized. Higher levels may increase gastrointestinal effects, photosensitivity and hepatotoxicity.
How serious is the interaction between Pirfenidone and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone adverse effects and liver enzymes, and reduce the pirfenidone dose if poorly tolerated.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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