Drug interactions
Pirfenidone + Talquetamab
Severity: Moderate
Pirfenidone and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, which can temporarily suppress CYP450 enzymes. Pirfenidone exposure may increase during step-up dosing and for some days afterward, raising the risk of its adverse effects.
What this interaction means in plain words
Pirfenidone and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirfenidone belongs to Miscellaneous; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP1A2 reduces pirfenidone metabolism.
What to do
Monitor for pirfenidone adverse effects and liver enzymes during talquetamab initiation and CRS. Reduce or interrupt pirfenidone if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Pirfenidone with Talquetamab?
MediHelp rates the interaction as moderate. Pirfenidone and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, which can temporarily suppress CYP450 enzymes. Pirfenidone exposure may increase during step-up dosing and for some days afterward, raising the risk of its adverse effects.
How serious is the interaction between Pirfenidone and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone adverse effects and liver enzymes during talquetamab initiation and CRS. Reduce or interrupt pirfenidone if toxicity appears.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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