Drug interactions
Piroxicam + Tenecteplase
Severity: Major
Piroxicam and Tenecteplase: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a thrombolytic that carries a high bleeding risk, and piroxicam inhibits platelet function and can injure GI mucosa. Concurrent use may increase the likelihood or severity of hemorrhage.
What this interaction means in plain words
Piroxicam and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piroxicam belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Pharmacodynamic additive bleeding risk: fibrinolysis combined with NSAID-mediated platelet inhibition and mucosal injury.
What to do
Review recent NSAID use before thrombolysis and monitor closely for bleeding afterward; avoid continuing the NSAID during and immediately after thrombolytic therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Piroxicam with Tenecteplase?
MediHelp rates the interaction as major. Piroxicam and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a thrombolytic that carries a high bleeding risk, and piroxicam inhibits platelet function and can injure GI mucosa. Concurrent use may increase the likelihood or severity of hemorrhage.
How serious is the interaction between Piroxicam and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review recent NSAID use before thrombolysis and monitor closely for bleeding afterward; avoid continuing the NSAID during and immediately after thrombolytic therapy.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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