Drug interactions
Piroxicam + Valganciclovir
Severity: Minor
Piroxicam and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may compete with ganciclovir for renal tubular secretion, potentially raising ganciclovir levels. NSAIDs can also reduce renal function, further impairing ganciclovir clearance and increasing hematologic toxicity.
What this interaction means in plain words
Piroxicam and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Piroxicam belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular anionic transport and NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and blood counts during co-therapy. Adjust the valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Piroxicam with Valganciclovir?
MediHelp rates the interaction as minor. Piroxicam and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Piroxicam may compete with ganciclovir for renal tubular secretion, potentially raising ganciclovir levels. NSAIDs can also reduce renal function, further impairing ganciclovir clearance and increasing hematologic toxicity.
How serious is the interaction between Piroxicam and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts during co-therapy. Adjust the valganciclovir dose to creatinine clearance.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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