Drug interactions
Pirtobrutinib + Sirolimus
Severity: Moderate
Pirtobrutinib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib weakly inhibits CYP3A4 and may increase sirolimus concentrations. Higher levels raise the risk of sirolimus toxicity such as cytopenias, hyperlipidemia and mouth ulcers.
What this interaction means in plain words
Pirtobrutinib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirtobrutinib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated sirolimus metabolism.
What to do
Monitor sirolimus trough concentrations when starting or stopping pirtobrutinib. Reduce the sirolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Pirtobrutinib with Sirolimus?
MediHelp rates the interaction as moderate. Pirtobrutinib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib weakly inhibits CYP3A4 and may increase sirolimus concentrations. Higher levels raise the risk of sirolimus toxicity such as cytopenias, hyperlipidemia and mouth ulcers.
How serious is the interaction between Pirtobrutinib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping pirtobrutinib. Reduce the sirolimus dose as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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