Drug interactions
Pirtobrutinib + Tacrolimus
Severity: Moderate
Pirtobrutinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib is a weak CYP3A4 inhibitor and may modestly increase tacrolimus levels. Higher levels may increase nephrotoxicity and neurotoxicity.
What this interaction means in plain words
Pirtobrutinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirtobrutinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 reduces tacrolimus metabolism.
What to do
Monitor tacrolimus trough levels and renal function when pirtobrutinib is started or stopped, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Pirtobrutinib with Tacrolimus?
MediHelp rates the interaction as moderate. Pirtobrutinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib is a weak CYP3A4 inhibitor and may modestly increase tacrolimus levels. Higher levels may increase nephrotoxicity and neurotoxicity.
How serious is the interaction between Pirtobrutinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when pirtobrutinib is started or stopped, and adjust the tacrolimus dose accordingly.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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